Transient Proteolytic Modification of Mesenchymal Stromal Cells Increases Lung Clearance Rate and Targeting to Injured Tissue

Systemic infusion of therapeutic cells would be the most practical and least invasive method of administration in many cellular therapies. One of the main obstacles especially in intravenous delivery of cells is a massive cell retention in the lungs, which impairs homing to the target tissue and may...

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Bibliographic Details
Main Authors: Kerkelä, Erja, Hakkarainen, Tanja, Mäkelä, Tuomas, Raki, Mari, Kambur, Oleg, Kilpinen, Lotta, Nikkilä, Janne, Lehtonen, Siri, Ritamo, Ilja, Pernu, Roni, Pietilä, Mika, Takalo, Reijo, Juvonen, Tatu, Bergström, Kim, Kalso, Eija, Valmu, Leena, Laitinen, Saara, Lehenkari, Petri, Nystedt, Johanna
Format: Artigo
Language:Inglês
Published: AlphaMed Press 2013
Subjects:
Enabling Technologies for Cell-Based Clinical Translation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697819/
https://ncbi.nlm.nih.gov/pubmed/23734061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0187
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