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Giardia duodenalis Arginine Deiminase Modulates the Phenotype and Cytokine Secretion of Human Dendritic Cells by Depletion of Arginine and Formation of Ammonia

Depletion of arginine is a recognized strategy that pathogens use to evade immune effector mechanisms. Depletion depends on microbial enzymes such as arginases, which are considered virulence factors. The effect is mostly interpreted as being a consequence of successful competition with host enzymes...

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Detalhes bibliográficos
Main Authors: Banik, Stefanie, Renner Viveros, Pablo, Seeber, Frank, Klotz, Christian, Ignatius, Ralf, Aebischer, Toni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697621/
https://ncbi.nlm.nih.gov/pubmed/23589577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00004-13
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