Lipopolysaccharide Modifications of a Cholera Vaccine Candidate Based on Outer Membrane Vesicles Reduce Endotoxicity and Reveal the Major Protective Antigen

The causative agent of the life-threatening gastrointestinal infectious disease cholera is the Gram-negative, facultative human pathogen Vibrio cholerae. We recently started to investigate the potential of outer membrane vesicles (OMVs) derived from V. cholerae as an alternative approach for a vacci...

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Autors principals: Leitner, Deborah R., Feichter, Sandra, Schild-Prüfert, Kristina, Rechberger, Gerald N., Reidl, Joachim, Schild, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Microbial Immunity and Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3697601/
https://ncbi.nlm.nih.gov/pubmed/23630951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01382-12
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