A Naturally Occurring Single Amino Acid Substitution in Human TRIM5α Linker Region Affects Its Anti-HIV Type 1 Activity and Susceptibility to HIV Type 1 Infection

TRIM5α is a factor contributing to intracellular defense mechanisms against retrovirus infection. Rhesus and cynomolgus monkey TRIM5αs potently restrict HIV-1, whereas human TRIM5α shows weak effects against HIV-1. We investigated the association between a single nucleotide polymorphism in the TRIM5...

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Detalhes bibliográficos
Main Authors: Nakayama, Emi E., Nakajima, Toshiaki, Kaur, Gurvinder, Mimaya, Jun-ich, Terunuma, Hiroshi, Mehra, Narinder, Kimura, Akinori, Shioda, Tatsuo
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696946/
https://ncbi.nlm.nih.gov/pubmed/23379364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2012.0369
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