Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA

RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However, the main barrier to the clinical use of RNAi remains the lack of efficient delivery vectors. Research has mainly concentrated on the intranasal route of delivery of short interfering RNA (siRNA...

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Detalhes bibliográficos
Main Authors: McCaskill, Jana, Singhania, Richa, Burgess, Melinda, Allavena, Rachel, Wu, Sherry, Blumenthal, Antje, McMillan, Nigel AJ
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696903/
https://ncbi.nlm.nih.gov/pubmed/23736774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.22
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