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MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes
Drug-induced block of the cardiac hERG (human Ether-à-go-go-Related Gene) potassium channel delays cardiac repolarization and increases the risk of Torsade de Pointes (TdP), a potentially lethal arrhythmia. A positive hERG assay has been embraced by regulators as a non-clinical predictor of TdP desp...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696896/ https://ncbi.nlm.nih.gov/pubmed/23812503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02100 |
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