Ca(2+)/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective

Atheroprotective flow exerts antioxidative and anti-inflammatory effects on vascular endothelial cells (ECs), in part through the induction of Sirtuin 1 (SIRT1), a class III histone deacetylase. The role of Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK)β in flow induction of SIRT1 both in...

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Autores principales: Wen, Liang, Chen, Zhen, Zhang, Fan, Cui, Xiaopei, Sun, Wei, Geary, Greg G., Wang, Yinsheng, Johnson, David A., Zhu, Yi, Chien, Shu, Shyy, John Y.-J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696824/
https://ncbi.nlm.nih.gov/pubmed/23754392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309354110
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