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On the Origin of Large Flexibility of P-glycoprotein in the Inward-facing State

P-glycoprotein (Pgp) is one of the most biomedically relevant transporters in the ATP binding cassette (ABC) superfamily due to its involvement in developing multidrug resistance in cancer cells. Employing molecular dynamics simulations and double electron-electron resonance spectroscopy, we have in...

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Main Authors: Wen, Po-Chao, Verhalen, Brandy, Wilkens, Stephan, Mchaourab, Hassane S., Tajkhorshid, Emad
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696692/
https://ncbi.nlm.nih.gov/pubmed/23658020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450114
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