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Effect of temozolomide on male gametes: an epigenetic risk to the offspring?
INTRODUCTION: Temozolomide is an oral alkylating agent with proven efficacy in recurrent high-grade glioma. The antitumour activity of this molecule is attributed to the inhibition of replication through DNA methylation. However, this methylation may also perturb other DNA-dependent processes, such...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696451/ https://ncbi.nlm.nih.gov/pubmed/23652788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10815-013-9999-8 |
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