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Inducible co-stimulator (ICOS) up-regulation on activated T-cells in chronic graft-vs.-host disease following dog-leukocyte-antigen-nonidentical hematopoietic cell transplantation: A potential therapeutic target

BACKGROUND: Inducible co-stimulator (ICOS), a member of the CD28 family of costimulatory molecules, is induced on CD4(+) and CD8(+) T-cells following their activation. ICOS functions as an essential immune regulator and ICOS blockade is a potential approach to immune modulation in allogeneic transpl...

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Dettagli Bibliografici
Autori principali: Sato, Masahiko, Storb, Rainer, Loretz, Carol, Stone, Diane, Mielcarek, Marco, Sale, George E., Rezvani, Andrew R., Graves, Scott S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696413/
https://ncbi.nlm.nih.gov/pubmed/23694952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318295c025
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