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Inducible co-stimulator (ICOS) up-regulation on activated T-cells in chronic graft-vs.-host disease following dog-leukocyte-antigen-nonidentical hematopoietic cell transplantation: A potential therapeutic target
BACKGROUND: Inducible co-stimulator (ICOS), a member of the CD28 family of costimulatory molecules, is induced on CD4(+) and CD8(+) T-cells following their activation. ICOS functions as an essential immune regulator and ICOS blockade is a potential approach to immune modulation in allogeneic transpl...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696413/ https://ncbi.nlm.nih.gov/pubmed/23694952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e318295c025 |
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