Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.

In cystic fibrosis (CF), epithelial cells are unable to normally up-regulate apical membrane Cl- secretion in response to agents which increase cyclic AMP, but they do increase Cl- secretion in response to increases in intracellular Ca2+. Since intracellular divalent cations regulate the expression...

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Detalles Bibliográficos
Publicado en:Mol Cell Biol
Main Authors: Bargon, J, Trapnell, B C, Chu, C S, Rosenthal, E R, Yoshimura, K, Guggino, W B, Dalemans, W, Pavirani, A, Lecocq, J P, Crystal, R G
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 1992
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC369631/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1372390/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.12.4.1872
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