Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.

In cystic fibrosis (CF), epithelial cells are unable to normally up-regulate apical membrane Cl- secretion in response to agents which increase cyclic AMP, but they do increase Cl- secretion in response to increases in intracellular Ca2+. Since intracellular divalent cations regulate the expression...

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Detalhes bibliográficos
Main Authors: Bargon, J, Trapnell, B C, Chu, C S, Rosenthal, E R, Yoshimura, K, Guggino, W B, Dalemans, W, Pavirani, A, Lecocq, J P, Crystal, R G
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369631/
https://ncbi.nlm.nih.gov/pubmed/1372390
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