Mitochondrial Bioenergetics of Metastatic Breast Cancer Cells in Response to Dynamic Changes in Oxygen Tension: Effects of HIF-1α

Solid tumors are characterized by regions of low oxygen tension (OT), which play a central role in tumor progression and resistance to therapy. Low OT affects mitochondrial function and for the cells to survive, mitochondria must functionally adapt to low OT to maintain the cellular bioenergetics. I...

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Main Authors: Diers, Anne R., Vayalil, Praveen K., Oliva, Claudia R., Griguer, Corinne E., Darley-Usmar, Victor, Hurst, Douglas R., Welch, Danny R., Landar, Aimee
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696014/
https://ncbi.nlm.nih.gov/pubmed/23840849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0068348
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