Pyruvate Kinase M2 Plays a Dual Role on Regulation of the EGF/EGFR Signaling via E-Cadherin-Dependent Manner in Gastric Cancer Cells

BACKGROUND AND AIMS: EGFR activation and PKM2 expression are instrumental in tumorigenesis. EGFR activation regulates PKM2 functions in a subcellular compartment-dependent manner and promotes gene transcription and tumor growth. In addition, PKM2 is upregulated in EGFR-induced pathways in glioma mal...

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Main Authors: Wang, Le-Yi, Liu, Yun-Peng, Chen, Li-Gang, Chen, Yan-Ling, Tan, Li, Liu, Jing-Jing, Jazag, Amarsanaa, Ren, Jian-Lin, Guleng, Bayasi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695906/
https://ncbi.nlm.nih.gov/pubmed/23840737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067542
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