Impact of IL28B gene polymorphisms on interferon-λ3 plasma levels during pegylated interferon-α/ribavirin therapy for chronic hepatitis C in patients coinfected with HIV

OBJECTIVES: The mechanism explaining the strong association between IL28B rs12979860 polymorphisms and treatment outcome in chronic hepatitis C remains unclear. We explore whether IL28B protein [interferon (IFN)-λ3] plasma levels may vary according to IL28B genotype and/or following pegylated IFN-α/...

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Detalhes bibliográficos
Main Authors: Rallón, Norma I., Soriano, Vincent, Naggie, Susanna, Restrepo, Clara, McHutchison, John, Vispo, Eugenia, Benito, José M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695611/
https://ncbi.nlm.nih.gov/pubmed/22294646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr598
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