Detection of γ-H2AX, a Biomarker for DNA Double-strand Breaks, in Urinary Bladders of N -Butyl- N -(4-Hydroxybutyl)-Nitrosamine-Treated Rats

To evaluate the potential role of DNA repair in bladder carcinogenesis, we performed an immunohistochemical analysis of expression of various DNA repair enzymes and γ-H2AX, a high-sensitivity marker of DNA double-strand breaks, in the urothelium of male F344 rats treated with N-butyl-N-(4-hydroxybut...

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Detalhes bibliográficos
Main Authors: Toyoda, Takeshi, Akagi, Jun-ichi, Cho, Young-Man, Mizuta, Yasuko, Onami, Saeko, Suzuki, Isamu, Ogawa, Kumiko
Formato: Artigo
Idioma:Inglês
Publicado em: Japanese Society of Toxicologic Pathology 2013
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3695345/
https://ncbi.nlm.nih.gov/pubmed/23914065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.26.215
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