Linezolid Exerts Greater Bacterial Clearance but No Modification of Host Lung Gene Expression Profiling: A Mouse MRSA Pneumonia Model

BACKGROUND: Linezolid (LZD) is beneficial to patients with MRSA pneumonia, but whether and how LZD influences global host lung immune responses at the mRNA level during MRSA-mediated pneumonia is still unknown. METHODS: A lethal mouse model of MRSA pneumonia mediated by USA300 was employed to study...

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Autores principales: Chen, Jiwang, Feng, Gang, Song, Yang, Wardenburg, Juliane B., Lin, Simon, Inoshima, Ichiro, Otto, Michael, Wunderink, Richard G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694879/
https://ncbi.nlm.nih.gov/pubmed/23826353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067994
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