Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction

Diabetes mellitus leads to vascular complications but the underlying signalling mechanisms are not fully understood. Here, we examined the role of ErbB2 (HER2/Neu), a transmembrane receptor tyrosine kinase of the ErbB/EGFR (epidermal growth factor receptor) family, in mediating diabetes-induced vasc...

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Main Authors: Akhtar, Saghir, Yousif, Mariam H. M., Dhaunsi, Gursev S., Sarkhouh, Fatma, Chandrasekhar, Bindu, Attur, Sreeja, Benter, Ibrahim F.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694874/
https://ncbi.nlm.nih.gov/pubmed/23826343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067813
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