Synergistic Cytotoxicity of Irinotecan and Cisplatin in Dual-Drug PSMA-Targeted Polymeric Nanoparticles

AIM: Two unexplored aspects for irinotecan and cisplatin (I&C) combination chemotherapy are (1) actively targeting both drugs to a specific diseased cell type and (2) delivering both drugs on the same vehicle to ensure their synchronized entry into the cell at a well-defined ratio. In this work...

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Main Authors: Valencia, Pedro M., Pridgen, Eric M., Perea, Brian, Gadde, Suresh, Sweeney, Christopher, Kantoff, Philip W., Lippard, Stephen J., Langer, Robert, Karnik, Rohit, Farokhzad, Omid C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694785/
https://ncbi.nlm.nih.gov/pubmed/23075285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/nnm.12.134
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