Small Internal Deletions in the Human Cytomegalovirus IE2 Gene Result in Nonviable Recombinant Viruses with Differential Defects in Viral Gene Expression

The human cytomegalovirus (HCMV) IE2 86-kDa protein is a key viral transactivator and an important regulator of HCMV infections. We used the HCMV genome cloned as a bacterial artificial chromosome (BAC) to construct four HCMV mutants with disruptions in regions of IE2 86 that are predicted to be imp...

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Detalles Bibliográficos
Main Authors: White, Elizabeth A., Clark, Charles L., Sanchez, Veronica, Spector, Deborah H.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC369462/
https://ncbi.nlm.nih.gov/pubmed/14747546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.4.1817-1830.2004
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