The COOH-terminal domain of the Rap1A (Krev-1) protein is isoprenylated and supports transformation by an H-Ras:Rap1A chimeric protein.

Although the Rap1A protein resembles the oncogenic Ras proteins both structurally and biochemically, Rap1A exhibits no oncogenic properties. Rather, overexpression of Rap1A can reverse Ras-induced transformation of NIH 3T3 cells. Because the greatest divergence in amino acid sequence between Ras and...

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Autores principales: Buss, J E, Quilliam, L A, Kato, K, Casey, P J, Solski, P A, Wong, G, Clark, R, McCormick, F, Bokoch, G M, Der, C J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1991
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC369437/
https://ncbi.nlm.nih.gov/pubmed/1899909
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