Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer

BACKGROUND: Pedigrees with multiple genotyped family members have been underutilised in breast cancer (BC) genetic-association studies. We developed a pedigree-based analytical framework to characterise single-nucleotide polymorphism (SNP) associations with BC risk using data from 736 BC families as...

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Detalhes bibliográficos
Main Authors: Barnes, D R, Barrowdale, D, Beesley, J, Chen, X, James, P A, Hopper, J L, Goldgar, D, Chenevix-Trench, G, Antoniou, A C, Mitchell, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3694253/
https://ncbi.nlm.nih.gov/pubmed/23756864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.277
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