Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cells

BACKGROUND: Binding of HIV to the chemokine coreceptor CXCR4 mediates viral fusion and signal transduction that promotes actin dynamics critical for HIV infection of blood resting CD4 T cells. It has been suggested that this gp120-mediated actin activity resembles the chemotactic actin dynamics medi...

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Bibliographic Details
Main Authors: Guo, Jia, Xu, Xuehua, Rasheed, Taban K, Yoder, Alyson, Yu, Dongyang, Liang, Huizhi, Yi, Fei, Hawley, Todd, Jin, Tian, Ling, Binhua, Wu, Yuntao
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693989/
https://ncbi.nlm.nih.gov/pubmed/23782904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-62
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