Genetic polymorphisms of collagen type I α1 chain (COL1A1) gene increase the frequency of low bone mineral density in the subgroup of children with juvenile idiopathic arthritis

BACKGROUND: Collagen type I is one of the key proteins involved in the maturation, development and mineralization of bone. Genetic polymorphisms of collagen type I alpha-1 chain (COL1A1) gene are associated with low bone mineral density and higher risk of fractures in adults and children. We hypothe...

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Detalhes bibliográficos
Main Authors: Kostik, Mikhail M, Smirnov, Arseniy M, Demin, Grigory S, Mnuskina, Marina M, Scheplyagina, Larisa A, Larionova, Valentina I
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3693906/
https://ncbi.nlm.nih.gov/pubmed/23763832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1878-5085-4-15
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