Attenuated RORC Expression in the Presence of EMT Progression in Somatotroph Adenomas following Treatment with Somatostatin Analogs Is Associated with Poor Clinical Recovery

Somatostatin analogs (SA) have been established as the first line medical treatment for acromegaly, but following long-term treatment, SA normalizes GH and IGF-I levels in only 40–60% of patients. The epithelial marker E-cadherin plays a crucial role in the epithelial mesenchymal transition (EMT) an...

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Bibliographic Details
Main Authors: Lekva, Tove, Berg, Jens Petter, Heck, Ansgar, Lyngvi Fougner, Stine, Olstad, Ole Kristoffer, Ringstad, Geir, Bollerslev, Jens, Ueland, Thor
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692554/
https://ncbi.nlm.nih.gov/pubmed/23825587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066927
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