Interleukin-21 Enhances Rituximab Activity in a Cynomolgus Monkey Model of B Cell Depletion and in Mouse B Cell Lymphoma Models

Rituximab, a monoclonal antibody targeting CD20 on B cells, is currently used to treat many subtypes of B cell lymphomas. However, treatment is not curative and response rates are variable. Recombinant interleukin-21 (rIL-21) is a cytokine that enhances immune effector function and affects both prim...

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Main Authors: Krejsa, Cecile M., Holly, Rick D., Heipel, Mark, Bannink, Ken M., Johnson, Rebecca, Roque, Richard, Heffernan, Jane, Hill, Julie, Chin, Lay, Wagener, Felecia, Shiota, Faith, Henderson, Katherine, Sivakumar, Pallavur V., Ren, Hong-Ping, Barahmand-pour, Fariba, Foster, Don, Clegg, Chris, Kindsvogel, Wayne, Ponce, Rafael, Hughes, Steven D., Waggie, Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692496/
https://ncbi.nlm.nih.gov/pubmed/23825648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067256
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