Binding of the 2F5 Monoclonal Antibody to Native and Fusion-Intermediate Forms of Human Immunodeficiency Virus Type 1 gp41: Implications for Fusion-Inducing Conformational Changes

We investigated how the broadly neutralizing monoclonal antibody 2F5 affects the human immunodeficiency virus type 1 envelope glycoprotein as it undergoes receptor-induced conformational changes and show that 2F5 binds both native and fusion-intermediate conformations, suggesting inhibition of a lat...

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Detalhes bibliográficos
Main Authors: de Rosny, Eve, Vassell, Russell, Jiang, Shibo, Kunert, Renate, Weiss, Carol D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC369236/
https://ncbi.nlm.nih.gov/pubmed/14963170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.5.2627-2631.2004
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