Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Intravenous administration of a novel recombinant rhesus mAb against the α4β7 gut-homing integrin (mAb) into rhesus macaques just prior to and during acute SIV infection resulted in significant decrease in plasma and gastrointestinal (GI) tissue viral load and a marked reduction in GI tissue provira...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Ansari, Aftab A., Reimann, Keith A., Mayne, Ann E., Takahashi, Yoshiaki, Stephenson, Susan T., Wang, Rijian, Wang, Xinyue, Li, Jichu, Price, Andrew A., Little, Dawn M., Zaidi, Mohammad, Lyles, Robert, Villinger, Francois
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691699/
https://ncbi.nlm.nih.gov/pubmed/21149598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003052
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires