Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

Intravenous administration of a novel recombinant rhesus mAb against the α4β7 gut-homing integrin (mAb) into rhesus macaques just prior to and during acute SIV infection resulted in significant decrease in plasma and gastrointestinal (GI) tissue viral load and a marked reduction in GI tissue provira...

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Main Authors: Ansari, Aftab A., Reimann, Keith A., Mayne, Ann E., Takahashi, Yoshiaki, Stephenson, Susan T., Wang, Rijian, Wang, Xinyue, Li, Jichu, Price, Andrew A., Little, Dawn M., Zaidi, Mohammad, Lyles, Robert, Villinger, Francois
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691699/
https://ncbi.nlm.nih.gov/pubmed/21149598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003052
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