Physical limits of cell migration: Control by ECM space and nuclear deformation and tuning by proteolysis and traction force

Cell migration through 3D tissue depends on a physicochemical balance between cell deformability and physical tissue constraints. Migration rates are further governed by the capacity to degrade ECM by proteolytic enzymes, particularly matrix metalloproteinases (MMPs), and integrin- and actomyosin-me...

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Bibliographic Details
Main Authors: Wolf, Katarina, te Lindert, Mariska, Krause, Marina, Alexander, Stephanie, te Riet, Joost, Willis, Amanda L., Hoffman, Robert M., Figdor, Carl G., Weiss, Stephen J., Friedl, Peter
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2013
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691458/
https://ncbi.nlm.nih.gov/pubmed/23798731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210152
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