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Theoretical Considerations and Practical Approaches to Address the Effect of Anti-drug Antibody (ADA) on Quantification of Biotherapeutics in Circulation

Continuous improvement in bioanalytical method development is desired in order to ensure the quality of the data and to better support pharmacokinetic (PK) and safety studies of biotherapeutics. One area that has been getting increasing attention recently is in the assessment of “free” and “total” a...

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Detalhes bibliográficos
Main Authors: Kelley, Marian, Ahene, Ago B., Gorovits, Boris, Kamerud, John, King, Lindsay E., McIntosh, Thomas, Yang, Jihong
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691419/
https://ncbi.nlm.nih.gov/pubmed/23543601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9468-4
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