Assessment of Juvenile Pigs to Serve as Human Pediatric Surrogates for Preclinical Formulation Pharmacokinetic Testing

Pediatric drug development is hampered by biological, clinical, and formulation challenges associated with age-based populations. A primary cause for this lack of development is the inability to accurately predict ontogenic changes that affect pharmacokinetics (PK) in children using traditional prec...

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Detalhes bibliográficos
Main Authors: Roth, Wyatt J., Kissinger, Candice B., McCain, Robyn R., Cooper, Bruce R., Marchant-Forde, Jeremy N., Vreeman, Rachel C., Hannou, Sophia, Knipp, Gregory T.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3691418/
https://ncbi.nlm.nih.gov/pubmed/23595360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-013-9482-6
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