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Combining intracellular selection with protein-fragment complementation to derive Aβ interacting peptides
Aggregation of the β-amyloid (Aβ) peptide into toxic oligomers is considered the primary event in the pathogenesis of Alzheimer's disease. Previously generated peptides and mimetics designed to bind to amyloid fibrils have encountered problems in solubility, protease susceptibility and the popu...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690830/ https://ncbi.nlm.nih.gov/pubmed/23708321 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzt021 |
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