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Fibroblast Growth Factor Receptor Signaling Is Essential for Normal Mammary Gland Development and Stem Cell Function

Fibroblast growth factor (FGF) signaling plays an important role in embryonic stem cells and adult tissue homeostasis, but the function of FGFs in mammary gland stem cells is less well defined. Both FGFR1 and FGFR2 are expressed in basal and luminal mammary epithelial cells (MECs), suggesting that t...

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Main Authors: Pond, Adam C., Bin, Xue, Batts, Torey, Roarty, Kevin, Hilsenbeck, Susan, Rosen, Jeffrey M.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690809/
https://ncbi.nlm.nih.gov/pubmed/23097355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1266
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