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Structural and functional analysis of perforin mutations in association with clinical data of familial hemophagocytic lymphohistiocytosis type 2 (FHL2) patients

Perforin plays a key role in the immune system via pore formation at the target cell membrane in the elimination of virus-infected and transformed cells. A vast number of observed mutations in perforin impair this mechanism resulting in a rare but fatal disease, familial hemophagocytic lymphohistioc...

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Detalhes bibliográficos
Main Authors: An, Omer, Gursoy, Attila, Gurgey, Aytemiz, Keskin, Ozlem
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690721/
https://ncbi.nlm.nih.gov/pubmed/23592409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2265
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