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Removal of the Spleen in Mice Alters the Cytokine Expression Profile of the Marrow Micro-environment and Increases Bone Formation
Splenectomized mice express progressively increased numbers of platelets in the blood and reduced numbers of megakaryocytes in the marrow with age. The megakaryocytes in the marrow of these animals express reduced levels of Gata1, a transcription factor necessary for their maturation. In addition, t...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690574/ https://ncbi.nlm.nih.gov/pubmed/19796235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2009.04968.x |
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