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Axonopathy is a compounding factor in the pathogenesis of Krabbe disease
Loss-of-function of the lysosomal enzyme galactosyl-ceramidase (GALC) causes the accumulation of the lipid raft-associated sphingolipid psychosine, the disruption of postnatal myelination, neurodegeneration and early death in most cases of infantile Krabbe disease. This work presents a first study t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690521/ https://ncbi.nlm.nih.gov/pubmed/21373782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-011-0814-2 |
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