Rhodiola crenulata and Its Bioactive Components, Salidroside and Tyrosol, Reverse the Hypoxia-Induced Reduction of Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of ROS-AMPK-PKCξ Pathway

Exposure to hypoxia leads to impaired pulmonary sodium transport, which is associated with Na,K-ATPase dysfunction in the alveolar epithelium. The present study is designed to examine the effect and mechanism of Rhodiola crenulata extract (RCE) and its bioactive components on hypoxia-mediated Na,K-A...

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Autors principals: Lee, Shih-Yu, Shi, Li-Shian, Chu, Hsin, Li, Min-Hui, Ho, Cheng-Wen, Lai, Feng-Yi, Huang, Chih-Yang, Chang, Tsu-Chung
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690265/
https://ncbi.nlm.nih.gov/pubmed/23840253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/284150
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