High-Dose, but Not Low-Dose, Aspirin Impairs Anticontractile Effect of Ticagrelor following ADP Stimulation in Rat Tail Artery Smooth Muscle Cells

Objective. To compare effects of low- versus high-dose aspirin coadministered with ticagrelor on the reactivity of vascular smooth muscle cells (VSMCs). Methods. Wistar rats were orally administered ticagrelor (10 mg/kg) and/or aspirin (2 or 10 mg/kg) (n = 7 per each of 4 groups) or placebo (n = 9)...

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Main Authors: Grześk, Grzegorz, Kozinski, Marek, Tantry, Udaya S., Wicinski, Michal, Fabiszak, Tomasz, Navarese, Eliano P., Grzesk, Elzbieta, Jeong, Young-Hoon, Gurbel, Paul A., Kubica, Jacek
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690229/
https://ncbi.nlm.nih.gov/pubmed/23841099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/928271
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