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Methotrexate catabolism to 7-hydroxy methotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplements
OBJECTIVE: Urinary excretion of methotrexate (MTX) and its catabolite 7-hydroxy-MTX (7-OH-MTX) were measured in two 24-hour collections after MTX therapy in patients with rheumatoid arthritis. The effect of folic and folinic acid supplements on this catabolism was determined in patients and in vitro...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3690194/ https://ncbi.nlm.nih.gov/pubmed/19644884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24685 |
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