Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients

AIMS: Aldo-ketoreductases have been implicated in the metabolism of doxorubicin. We sought to assess the influence of AKR1C3 genetic variants on doxorubicin metabolism. METHODS: We sequenced AKR1C3 exon 5 and genotyped seven functional single nucleotide polymorphisms in CBR3, ABCB1 and SLC22A16 invo...

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Detalhes bibliográficos
Main Authors: Voon, Pei Jye, Yap, Hui Ling, Ma, Cho-Yee-Thu, Lu, Fan, Wong, Andrea L A, Sapari, Nur Sabrina, Soong, Richie, Soh, Thomas I P, Goh, Boon-Cher, Lee, How-Sung, Lee, Soo-Chin
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2013
Assuntos:
Pharmacogenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690108/
https://ncbi.nlm.nih.gov/pubmed/23116553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12021
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