The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of inhaled fluticasone furoate and vilanterol trifenatate in healthy subjects

AIM: To investigate the effects of the cytochrome P450 3A4 (CYP3A4) inhibitor ketoconazole on the pharmacokinetics (PK) and pharmacodynamics of fluticasone furoate (FF) and vilanterol trifenatate (VI). METHODS: Two double-blind, randomized, placebo-controlled, two-way crossover studies in healthy su...

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Detaylı Bibliyografya
Asıl Yazarlar: Kempsford, Rodger, Allen, Ann, Bal, Joanne, Rubin, David, Tombs, Lee
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2013
Konular:
Drug Interactions
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690106/
https://ncbi.nlm.nih.gov/pubmed/23116485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12019
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