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FEASIBILITY AND DOSE DISCOVERY ANALYSIS OF ZOLEDRONIC ACID WITH CONCURRENT CHEMOTHERAPY IN THE TREATMENT OF NEWLY DIAGNOSED METASTATIC OSTEOSARCOMA: A REPORT FROM THE CHILDEREN’S ONCOLOGY GROUP

AIM: Patients with metastatic osteosarcoma (OS) have a poor outcome with conventional therapies. Zoledronic acid (ZA) is a third-generation bisphosphonate that reduces skeletal-related events in many adult cancers, and preclinical data suggests a possible benefit in OS. This study assessed the maxim...

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Detalhes bibliográficos
Main Authors: Goldsby, Robert E., Fan, Timothy M., Villaluna, Doojduen, Wagner, Lars M., Isakoff, Michael S., Meyer, James, Randall, R. Lor, Lee, Sharon, Kim, Grace, Bernstein, Mark, Gorlick, Richard, Krailo, Mark, Marina, Neyssa
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689577/
https://ncbi.nlm.nih.gov/pubmed/23664013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2013.03.018
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