Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway

Selenoprotein P (SeP) was recently identified as a hepatokine that induces insulin resistance (IR) in rodents and humans. Recent clinical trials have shown that salsalate, a prodrug of salicylate, significantly lowers blood glucose levels and increases adiponectin concentrations. We examined the eff...

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Detalhes bibliográficos
Main Authors: Jung, Tae Woo, Choi, Hae Yoon, Lee, So Young, Hong, Ho Cheol, Yang, Sae Jeong, Yoo, Hye Jin, Youn, Byung-Soo, Baik, Sei Hyun, Choi, Kyung Mook
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689003/
https://ncbi.nlm.nih.gov/pubmed/23825542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066529
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