Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain

Rifampin has been used for the treatment of bacterial infections for many years. Clinically, rifampin has been found to possess immunomodulatory effects. However, the molecular target responsible for the immunosuppressive effects of rifampin is not known. Herein, we show that rifampin binds to myelo...

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Main Authors: Wang, Xiaohui, Grace, Peter M., Pham, Michael N., Cheng, Kui, Strand, Keith A., Smith, Christina, Li, Jing, Watkins, Linda R., Yin, Hang
Format: Artigo
Jezik:Inglês
Izdano: Federation of American Societies for Experimental Biology 2013
Teme:
Research Communications
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688759/
https://ncbi.nlm.nih.gov/pubmed/23568774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-222992
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