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Rifampin inhibits Toll-like receptor 4 signaling by targeting myeloid differentiation protein 2 and attenuates neuropathic pain

Rifampin has been used for the treatment of bacterial infections for many years. Clinically, rifampin has been found to possess immunomodulatory effects. However, the molecular target responsible for the immunosuppressive effects of rifampin is not known. Herein, we show that rifampin binds to myelo...

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Autores principales: Wang, Xiaohui, Grace, Peter M., Pham, Michael N., Cheng, Kui, Strand, Keith A., Smith, Christina, Li, Jing, Watkins, Linda R., Yin, Hang
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688759/
https://ncbi.nlm.nih.gov/pubmed/23568774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-222992
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