Designed Azolopyridinium Salts Block Protective Antigen Pores In Vitro and Protect Cells from Anthrax Toxin

BACKGROUND: Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been...

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Main Authors: Beitzinger, Christoph, Bronnhuber, Anika, Duscha, Kerstin, Riedl, Zsuzsanna, Huber-Lang, Markus, Benz, Roland, Hajós, György, Barth, Holger
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688708/
https://ncbi.nlm.nih.gov/pubmed/23840407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0066099
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