Disconnecting mitochondrial content from respiratory chain capacity in PGC-1 deficient skeletal muscle

The transcriptional coactivators PGC-1α and PGC-1β are widely thought to be required for mitochondrial biogenesis and fiber typing in skeletal muscle. We show here that mice lacking both PGC-1s in myocytes do indeed have profoundly deficient mitochondrial respiration, but surprisingly have preserved...

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Main Authors: Rowe, Glenn C., Patten, Ian S., Zsengeller, Zsuzsanna K., El-Khoury, Riyad, Okutsu, Mitsuharu, Bampoh, Sophia, Koulisis, Nicole, Farrell, Caitlin, Hirshman, Michael F., Yan, Zhen, Goodyear, Laurie J., Rustin, Pierre, Arany, Zolt
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3688451/
https://ncbi.nlm.nih.gov/pubmed/23707060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.04.023
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