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TGF-β signalling and reactive oxygen species drive fibrosis and matrix remodelling in myxomatous mitral valves
AIMS: Myxomatous mitral valve disease (MMVD) is associated with leaflet thickening, fibrosis, matrix remodelling, and leaflet prolapse. Molecular mechanisms contributing to MMVD, however, remain poorly understood. We tested the hypothesis that increased transforming growth factor-β (TGF-β) signallin...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3687751/ https://ncbi.nlm.nih.gov/pubmed/23554457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvt083 |
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