Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration

Phosphatidylinositol 4-phosphate 5-kinase type I γ (PIPKIγ90) binds talin and localizes at focal adhesions (FAs). Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) generated by PIPKIγ90 is essential for FA formation and cell migration. On the other hand, PIPKIγ90 and the β-integrin tail compete for o...

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Main Authors: Li, Xiang, Zhou, Qi, Sunkara, Manjula, Kutys, Matthew L., Wu, Zhaofei, Rychahou, Piotr, Morris, Andrew J., Zhu, Haining, Evers, B. Mark, Huang, Cai
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687698/
https://ncbi.nlm.nih.gov/pubmed/23572508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.117044
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