Conserved C-Terminal Threonine of Hepatitis C Virus NS3 Regulates Autoproteolysis and Prevents Product Inhibition

Inspection of over 250 hepatitis C virus (HCV) genome sequences shows that a threonine is strictly conserved at the P1 position in the NS3-NS4A (NS3-4A) autoproteolysis junction, while a cysteine is maintained as the P1 residue in all of the putative trans cleavage sites (NS4A-4B, NS4B-5A, and NS5A-...

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Detalhes bibliográficos
Main Authors: Wang, Wenyan, Lahser, Frederick C., Yi, MinKyung, Wright-Minogue, Jacquelyn, Xia, Ellen, Weber, Patricia C., Lemon, Stanley M., Malcolm, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC368748/
https://ncbi.nlm.nih.gov/pubmed/14694101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.2.700-709.2004
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